Frozen Embryo Transfer

PFC Team's picture
July 10, 2018

It’s not every day that a woman gives birth to a baby conceived within a year of her own conception. On November 25, 2017, Emma Wren Gibson’s delivery became a world record—a healthy birth from the longest known frozen embryo, originally cryopreserved in 1992.1

A 20-year-old frozen embryo was the previous oldest known embryo leading to a successful birth. However, it is not possible to confirm the oldest embryos with any certainty. That’s because American companies aren’t required to report the age of embryos, only the outcome of the pregnancies.

PFC Team's picture
December 06, 2017

Which type of transfer—fresh or freeze-only—leads to higher implantation and ongoing pregnancy rates (OPR)? A recent study was the largest to make this comparison, finding that freeze-only transfers are often the clear winners.1 Why is this so? It may have something to do with the delicate “dance” between the embryo and the lining of the uterus (endometrium).

Reproductive synchrony. For implantation to be successful, this embryo-endometrial dance must be well choreographed. The embryo must bring the right complement of chromosomes to its “dance partner,” and the endometrium must establish an environment that’s welcoming for the embryo. A receptive endometrium depends upon endometrial gene expression as well as responses to hormones throughout different phases of the menstrual cycle.

PFC Team's picture
November 11, 2016

In a randomized controlled trial (RCT) at a private fertility center, researchers found basic parity in outcomes between fresh and frozen transfers.1

Fresh or frozen transfers. Conducting the study between January 2014 and October 2015, the researchers randomized 179 patients on the day of hCG administration to either a fresh transfer (88 women) or a frozen thawed transfer (91 women).

Embryologists biopsied blastocysts on Day 5 or 6. Comprehensive chromosome screening (CCS) was performed using high-resolution next generation sequencing—a quicker, cheaper, and more accurate method of DNA sequencing. Depending upon availability and patient preference, physicians transferred 1 to 2 euploid embryos with a balanced set of chromosomes.

PFC Team's picture
December 16, 2014

San Francisco, CA – December 16, 2014 - The Pacific Coast Reproductive Society has accepted a Pacific Fertility Center (PFC) paper for oral presentation at its 63rd Annual Meeting, which runs from March 11-15, 2015, in Rancho Mirage, CA. The paper is entitled “Timing of Blastocyst Hatching after Vitrification and Warming: Impact on Clinical Pregnancy Rate.” Out of 100 submissions, it is one of eight selected for oral presentation.  

A strong membrane (zona pellucida-ZP) forms around the ovum during development in the ovary. Previous evidence suggested that freezing (vitrification) alters the properties of this membrane, possibly warranting its removal prior to frozen embryo transfer (FET) in certain cases.

Dr. Conaghan's picture
December 04, 2012
Wall Street Journal Article

This year we are seeing more news articles on the use of frozen embryos and the incredible benefits that they bring to IVF patients.  A recent article in the Wall Street Journal, “New Strategy may Boost Fertility Clinic Success Rates”, highlights the benefits and success of embryo freezing.  We have written many times about vitrification here in the pages of Fertility Flash, as PFC was an early adopter of the new vitrification technology and we have been using it exclusively for oocytes and embryos since 2007.  Our success rates, shown below, speak for themselves. 

Vitrification is the new technology that has changed embryo freezing dramatically. Vitrification allows embryos to better tolerate and survive a trip to the freezer.  Better embryos mean higher implantation rates and more pregnancies, with reduced risk.