It may not have always gotten the attention it deserves. But in several cases infertility can be linked to the man—not the woman. According to Resolve, approximately 30% of infertility is due to a male factor and 30% to a female factor. In the remaining cases, it is problems in both partners or unexplained. Often, for male infertility, the underlying cause remains a bit of a black box.
Now, researchers from Sweden’s Karolinska Institutet1 have identified a possible cause in men with a condition that increases the risk of developing autoimmune disease—that’s where the immune system attacks and damages healthy cells. Infertility is common in both sexes with the disease, called autoimmune polyendocrine syndrome type 1 (APS1).
Although it was previously known that APS1 acted against the ovaries in women, how the disease affected males was unknown. To learn more, researchers examined 93 men and women with APS1.