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PFC Infertility Doctor Blog

The Infertility Blog

June 08, 2015

The argument for single embryo transfer—one we’ve been making for quite some time—seems to keep gathering steam. The latest support has come from a recently published study using data from the national database for IVF centers’ information from 2006 to 2012.1

The study looked at live birth rates (LBRs) both from elective single embryo transfer (SET) and dual embryo transfer (DET). You might be surprised by the findings. The rates of live births were just as good—or better—for two SET cycles as for one DET cycle. In some patients, the live birth rate was up to 20 percent higher with two SET cycles.

May 28, 2015

Using data from 2013—the most recent available—Pacific Fertility Center (PFC) reports that live birth success rates using warmed embryos have more than doubled during the past 6 years in women in their late 30s.  Regardless of age, implantation and ongoing pregnancy rates of 50–75 percent are routine after single embryo transfer.

Along with improved freezing technology and biopsy methods, much of this success at PFC and elsewhere is due to advances in chromosomal screening, said Lauri Black, a certified genetic counselor at PFC.

Advances in genetic testing
“We’ve offered chromosome screening for well over a decade,” she said, “but PFC became an enthusiastic early adopter of comprehensive chromosome screening (CCS) due to its greater accuracy and effectiveness over previous methods. We now offer CCS to the majority of our patients.”

May 26, 2015

From Asia to Europe to North America, many countries are reporting falling fertility rates. Of course, infertility affects many couples personally, as you well know. But it also is a public health issue with broad economic implications, including rising health care expenditures for a rapidly aging population. For example, if growth continues at the current rate, 19 percent of the U.S. population will be over 65 by the year 2030.1

Rapid declines. In Asia, fertility rates are lower than global rates worldwide. In China specifically, infertility has risen from 1 to 3 percent in the 1970s to about 10 percent today. In some cities, the rate is as high as 18 percent.2 In Europe, couples at fertility clinics are reporting infertility increases of 8 to 9 percent each year.3

May 19, 2015

San Francisco, CA – May 19, 2015 – Unprecedented high pregnancy rates combined with low pregnancy risks. That’s the promise of elective single embryo transfer (eSET), when combined with comprehensive chromosome screening (CCS) and other technologies. Today, with their new program, Pacific Fertility Center (PFC) is delivering on that promise, achieving pregnancy rates ranging from 50–75 percent per transfer and multiple gestation rates of just 2 percent—much lower than the 20–30 percent typical of traditional in vitro fertilization (IVF).

May 18, 2015

At the recent 2015 Pacific Coast Reproductive Society (PCRS) meeting, three papers received the PCRS Allied Health Professional Award, which recognizes outstanding presentation in specialties such as reproductive endocrinology, urology, gynecology, nursing, and genetics.

PFC’s Sergio Vaccari received one of these awards for his paper on timing of blastocyst hatching after vitrification. Another abstract focused on the potential relationship between intracytoplasmic sperm injection (ICSI) and aneuploidy,1 an abnormal number of chromosomes. In most cases, aneuploid embryos do not implant or they result in early miscarriage. Down syndrome (Trisomy 21) is a rare example of aneuploidy that can result in a live birth.

What is ICSI?
Introduced in 1992, ICSI is an IVF procedure where a single sperm is injected directly into an egg. ICSI is used for: