PCRS Update: Sergio's Poster
Another overview of one of the posters PFC presented at PCRS this year:
Time-Lapse Imaging May Improve Implantation Rates for Cleavage-Stage or Blastocyst Transfer
high or low blastocyst development probability for each embryo after just 48 hours in the incubator. Currently, the best embryo selection method available is a subjective assessment using morphology (how an embryo looks) and rate of development. The lack of other markers of embryo viability has led to patients transferring multiple embryos to increase their chance of pregnancy. Most patients in the United States are still transferring 2 or more embryos in fresh IVF cycles, which results in twin pregnancy rates consistently above 30%. Greater utilization of eSET (Single Embryo Transfer) requires improved and objective selection methods that can reliably identify viable embryos in a cohort. The addition of time lapse imaging results to the D3 (Day 3) morphology assessment predicts slightly higher implantation rates (IR) for good D3 embryos (55%) compared to fair/poor embryos (42%). For morphologically good quality blastocysts, the implantation rate was not impacted by the time lapse prediction (56% without, 55% with a high score and 55% with a low score). However, time lapse discriminated well among poor quality blastocysts (IR was 47% for high, 31% for low and 27% when using morphology only without time lapse). Similarly, early and expanding blastocysts had better IRs with an time lapse high score (50% and 43%) compared to those scored low (30% and 36%) and those scored by morphology only (33% and 36%). This study shows that for D3 embryos, the information provided by time lapse was a good indicator of which embryos would make blastocysts and which would implant after transfer. If blastocyst morphology was fair or poor quality, or the blastocysts were not fully expanded, the time lapse information provided a valuable additional parameter indicating which embryos would implant.
- Sergio Vaccari, PhD