What Everyone Should Know About Ethnic-Based Genetic Screening Before Pregnancy
Posted on August 12, 2009 by Inception Fertility
| Ancestral Population | Genetic Desease | Carrier Frequency | Detection Rate\* |
| All | cystic fibrosis | Approximately 4% in people of European (and Ashkenazi Jewish) ancestry and less common in other populations | Approximately 88% for Europeans, 94% for Ashkenazi Jewish ancestry, less accurate for others |
| Ashkenazi (Eastern European) Jewish ancestry | cystic fibrosis, Tay Sachs, Canavan, familial dysautonomia | Approximately 3% for Tay Sachs, 2% for Canavan and 3% for familial dysautonomia | Approximately 94-99%, (depending on the condition tested) |
| African/African-American, Chinese, Southeast Asian, or Mediterranean ancestry | Hemoglobinopathies, such as sickle cell anemia and thalassemia | Approximately 10% of African-Americans are sickle cell carriers; 5-6% of Asians and 12% of some Mediterranean populations are thalassemia carriers. | Variable depending on method, but very high (in the 90 percentiles) |
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